KOSCHMANN LAB

The Koschmann lab is studying the molecular mechanisms by which mutations in pediatric High-Grade Glioma (HGG) and Diffuse Intrinsic Pontine Glioma (DIPG) can be therapeutically targeted. The Koschmann Lab’s work in precision medicine pushes the boundaries of targeted therapies and precision diagnostics for children diagnosed with these brain tumors. Through highly collaborative basic, translational, and clinical research, the Koschmann Lab strives towards improving outcomes and providing hope for children fighting these devastating diseases.



Genetic Drivers of HGG and  DIPG

 

The Koschmann lab is studying the molecular mechanisms by which mutations in pediatric High-Grade Glioma (HGG) and Diffuse Intrinsic Pontine Glioma (DIPG) can be therapeutically targeted. The Koschmann Lab’s work in precision medicine pushes the boundaries of targeted therapies and precision diagnostics for children diagnosed with these brain tumors. Through highly collaborative basic, translational, and clinical research, the Koschmann Lab strives towards improving outcomes and providing hope for children fighting these devastating diseases.


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BBB-Adapted Precision Medicine

 

The Koschmann Lab is working to harness understanding of the blood-brain barrier (BBB) to optimize precision medicine therapies for pediatric brain tumors.  Dr. Koschmann developed and co-facilitates the UM Brain Tumor Precision Medicine conference at the University of Michigan. In this multi-disciplinary and multi-institutional conference, molecular results from pediatric brain tumor patients are incorporated into their treatment. Through collaborations developped in the UM Brain Tumor Precision Medicine conference , the Koschmann lab is working to develop new algorithms for the use of molecularly targeted therapy for children and young adults with brain tumors, based on selection of drugs with the highest likelihood of crossing the highly selective blood brain barrier.
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Clinical Trials and Spinal Fluid (CSF) Monitoring

 

The Koschmann lab is applying a novel precision medicine approach accounting for both unique tumor biology and optimization of blood brain barrier penetration.  We are performing correlate biology work on ongoing precision medicine trials for children and young adults with brain tumors at the University of Michigan, including correlation of spinal fluid analysis with surveillance MRIs.


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About Pediatric DIPG and HGG

Pediatric high-grade gliomas (HGGs) and diffuse intrinsic pontine gliomas (DIPG) are brain tumors that are diagnosed in children.  Recent advances have shed light on the molecular drivers and exposed potential new therapeutic targets.
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DONORS


 

Since her Wilms Tumor diagnosis in early 2016, 11-year-old Vara Gordon has made a commitment to advancing research in pediatric cancer. Vara met with Dr. Carl Koschmann and his lab and witnessed the great strides they had made in brain tumor research. And despite her own cancer being localized to her kidneys, Vara chose to support Koschmann Lab after seeing their incredible potential to help children with the most aggressive forms of brain tumors.